Connection.create_function

>>> import hashlib
>>> def md5sum(t):
...     return hashlib.md5(t).hexdigest()
>>> con = sqlite3.connect(":memory:")
>>> con.create_function("md5", 1, md5sum)
>>> for row in con.execute("SELECT md5(?)", (b"foo",)):
...     print(row)
('acbd18db4cc2f85cedef654fccc4a4d8',)
>>> con.close()